--- title: A new technique could accelerate the development of RNA... description: MIT researchers developed an automated technique for producing lipid nanoparticles (LNPs) used to deliver RNA and DNA therapeutics, offering precise control... canonical: https://daily.dev/posts/a-new-technique-could-accelerate-the-development-of-rna-therapies-juhusvryr twitter:card: summary_large_image twitter:site: @dailydotdev og:type: website og:site_name: daily.dev og:title: A new technique could accelerate the development of RNA therapies | daily.dev og:description: MIT researchers developed an automated technique for producing lipid nanoparticles (LNPs) used to deliver RNA and DNA therapeutics, offering precise control... og:url: https://daily.dev/posts/a-new-technique-could-accelerate-the-development-of-rna-therapies-juhusvryr og:image: https://api.daily.dev/og/posts/juhUsVrYR.png og:image:alt: A new technique could accelerate the development of RNA therapies og:image:width: 1200 og:image:height: 630 og:locale: en --- > ## Documentation Index > Fetch the complete documentation index at: https://daily.dev/llms.txt > Use this file to discover all available pages before exploring further. # A new technique could accelerate the development of RNA therapies **[MIT News](https://daily.dev/sources/mit)** · 6 min read · 0 upvotes · 0 comments ## Summary MIT researchers developed an automated technique for producing lipid nanoparticles (LNPs) used to deliver RNA and DNA therapeutics, offering precise control over particle size and shape. The process runs without human intervention, using a two-step mixing method combined with real-time light-scattering measurement to hit target particle sizes. Data from the automated experiments was used to train a machine-learning model that predicts which process parameters yield a desired size or shape, potentially speeding up development of new RNA therapeutics. The team has filed a patent and is commercializing the work through a new company, BIZON Labs, via MIT's delta v accelerator. ## Full article daily.dev links to this article rather than hosting it. Read it at the original source: ## Questions this post answers ### How does the two-step mixing process control the size of lipid nanoparticles for RNA delivery? Mixing mRNA and lipids at equal flow rates first, then adding more buffer after a delay, halts particle growth at a controllable point. Longer delays before the second mixing step produce larger particles, while shorter delays keep particles small, giving researchers a tunable lever over nanoparticle size without changing the lipid composition. _Anyone optimizing RNA delivery formulations can follow ongoing lipid nanoparticle research on daily.dev._ ### Why does the size of a lipid nanoparticle matter for RNA therapeutics? Particle size determines where in the body the nanoparticle is most likely to end up, so an LNP-based therapeutic made at 150 nanometers will behave very differently from one made at 70 nanometers even with identical composition otherwise. This makes precise size control critical for targeting specific organs and tissues. _Researchers tracking delivery-vehicle design trade-offs can follow this kind of therapeutics research on daily.dev._ ## Similar posts on daily.dev - [Particles that enhance mRNA delivery could reduce vaccine dosage and costs](https://daily.dev/posts/particles-that-enhance-mrna-delivery-could-reduce-vaccine-dosage-and-costs-r5zvcmesa) · MIT News · 0 upvotes · 0 comments - [New formulation helps RNA vaccines withstand high temperatures](https://daily.dev/posts/new-formulation-helps-rna-vaccines-withstand-high-temperatures-vuuovhjtp) · MIT News · 0 upvotes · 0 comments - [Researchers develop modular nanorobot](https://daily.dev/posts/researchers-develop-modular-nanorobot-jodudiywa) · Robohub · 0 upvotes · 0 comments - [Amping up T cells to target cancer](https://daily.dev/posts/amping-up-t-cells-to-target-cancer-9kzgfcilx) · MIT Technology Review · 0 upvotes · 0 comments --- Tags: [#machine-learning](https://daily.dev/tags/machine-learning), [#automation](https://daily.dev/tags/automation), [#biotech](https://daily.dev/tags/biotech) [View this post on daily.dev](https://daily.dev/posts/a-new-technique-could-accelerate-the-development-of-rna-therapies-juhusvryr) ```json {"@context":"https://schema.org","@graph":[{"@type":"Organization","@id":"https://daily.dev/#organization","name":"daily.dev","url":"https://daily.dev","logo":{"@type":"ImageObject","url":"https://daily.dev/apple-touch-icon.png","width":180,"height":180},"sameAs":["https://twitter.com/dailydotdev","https://github.com/dailydotdev","https://www.linkedin.com/company/daily-dev-ltd"]},{"@type":"WebSite","@id":"https://daily.dev/#website","url":"https://daily.dev","name":"daily.dev","publisher":{"@id":"https://daily.dev/#organization"},"potentialAction":{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https://daily.dev/search?q={search_term_string}"},"query-input":"required name=search_term_string"}}]} {"@context":"https://schema.org","@type":"TechArticle","headline":"A new technique could accelerate the development of RNA therapies","url":"https://daily.dev/posts/a-new-technique-could-accelerate-the-development-of-rna-therapies-juhusvryr","mainEntityOfPage":{"@type":"WebPage","@id":"https://daily.dev/posts/a-new-technique-could-accelerate-the-development-of-rna-therapies-juhusvryr"},"datePublished":"2026-09-25T17:30:31.290Z","dateModified":"2026-09-25T17:30:50.845Z","description":"MIT researchers developed an automated technique for producing lipid nanoparticles (LNPs) used to deliver RNA and DNA therapeutics, offering precise control...","image":"https://media.daily.dev/image/upload/f_auto,q_auto/v1/posts/c5c21a10085f5ed3a0e3b83fccfd05ce?_a=AQAEuop","thumbnailUrl":"https://media.daily.dev/image/upload/f_auto,q_auto/v1/posts/c5c21a10085f5ed3a0e3b83fccfd05ce?_a=AQAEuop","isAccessibleForFree":true,"articleSection":"MIT News","inLanguage":"en","publisher":{"@type":"Organization","name":"daily.dev","url":"https://daily.dev","logo":{"@type":"ImageObject","url":"https://daily.dev/apple-touch-icon.png","width":180,"height":180}},"author":{"@type":"Organization","name":"MIT News","logo":"https://media.daily.dev/image/upload/t_logo,f_auto/v1/logos/881e20a40aa44b12ba4bd27f5c14289d","url":"https://daily.dev/sources/mit"},"commentCount":0,"discussionUrl":"https://daily.dev/posts/a-new-technique-could-accelerate-the-development-of-rna-therapies-juhusvryr","interactionStatistic":[{"@type":"InteractionCounter","interactionType":{"@type":"LikeAction"},"userInteractionCount":0},{"@type":"InteractionCounter","interactionType":{"@type":"CommentAction"},"userInteractionCount":0}],"keywords":"machine-learning,automation,biotech","timeRequired":"PT6M"} {"@context":"https://schema.org","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://daily.dev"},{"@type":"ListItem","position":2,"name":"MIT News","item":"https://daily.dev/sources/mit"},{"@type":"ListItem","position":3,"name":"A new technique could accelerate the development of RNA therapies"}]} {"@context":"https://schema.org","@type":"FAQPage","@id":"https://daily.dev/posts/a-new-technique-could-accelerate-the-development-of-rna-therapies-juhusvryr#faq","mainEntity":[{"@type":"Question","name":"How does the two-step mixing process control the size of lipid nanoparticles for RNA delivery?","acceptedAnswer":{"@type":"Answer","text":"Mixing mRNA and lipids at equal flow rates first, then adding more buffer after a delay, halts particle growth at a controllable point. 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