Mathematical optimization is a prescriptive AI discipline that finds provably optimal decisions under real-world constraints — complementing machine learning's probabilistic predictions. Unlike ML, which learns patterns from data, optimization applies deductive reasoning to deliver definitive answers for complex operational problems like routing, scheduling, and manufacturing sequencing. AWS's Generative AI Innovation Center uses a four-step framework (Discover, Model, Solve, Architect) to tackle these challenges. Real-world results include a 10% robot cycle time improvement for BMW, up to 24% middle-mile logistics cost savings for Delivery Hero, and a theoretical 7–46% workforce cost reduction for Australian Red Cross Lifeblood. These projects have been productized into reusable solutions: ROaDS for vehicle routing and WISE for workforce scheduling.