Microsoft Agent 365 is a control plane for managing, securing, and governing AI agents across an organization — covering Microsoft-native agents, third-party agents, and custom-built agents on any cloud. The session walks through three pillars: observability (agent registry, usage analytics), governance (policy templates aggregating Entra, Defender, Purview, and SharePoint controls), and security (real-time threat protection, prompt injection defense, data loss prevention). A live demo shows onboarding a LangChain/Node.js travel agent using the Agent 365 SDK and GitHub Copilot skills, giving it an Entra agent identity, OpenTelemetry observability, and MCP server integrations for Word and OneDrive. The admin experience in Microsoft 365 Admin Center provides a unified registry with registry sync for Amazon Bedrock and Google Vertex AI agents, risk detection, automated lifecycle rules, and per-agent activity dashboards. GenSpark (Jenspark) shares how they integrated the Python SDK to reuse Microsoft's identity, MCP tools, and Purview audit capabilities without building their own security layer.