--- title: "Fine-Tuning Biological Foundation Models with LoRA Using NVIDIA BioNeMo Recipes" url: https://daily.dev/posts/fine-tuning-biological-foundation-models-with-lora-using-nvidia-bionemo-recipes-veoulundb source_url: https://developer.nvidia.com/blog/fine-tuning-biological-foundation-models-with-lora-using-nvidia-bionemo-recipes type: article source: "NVIDIA Developer" published: 2026-06-15T18:11:04.908Z updated: 2026-06-17T16:20:16.702Z tags: ["ai", "lora"] reading_time: 12 upvotes: 1 comments: 0 language: en --- > ## Documentation Index > Fetch the complete documentation index at: https://daily.dev/llms.txt > Use this file to discover all available pages before exploring further. # Fine-Tuning Biological Foundation Models with LoRA Using NVIDIA BioNeMo Recipes **[NVIDIA Developer](https://daily.dev/sources/nvidiadev)** · 12 min read · 1 upvotes · 0 comments ## Summary NVIDIA BioNeMo Recipes provides step-by-step workflows for fine-tuning large biological foundation models using LoRA (Low-Rank Adaptation), enabling parameter-efficient adaptation on a single workstation GPU. Two case studies are presented: ESM2-3B (protein language model) fine-tuned for protein secondary structure prediction achieving accuracy competitive with state-of-the-art baselines (Q3: 84.80%, Q8: 74.30%), and Evo2-1B (DNA language model) fine-tuned for splice-site classification, jumping from 52.3% (head-only) to 96.6% accuracy while training only ~1.4% of parameters. The recipes integrate NVIDIA Transformer Engine, Megatron-Bridge, and sequence packing (THD format) for ~5.5x throughput improvement. Both workflows complete in under one hour on an NVIDIA RTX 6000 Blackwell GPU. ## Full article daily.dev links to this article rather than hosting it. Read it at the original source: ## Similar posts on daily.dev - [Fine-Tuning NVIDIA Cosmos Predict 2.5 with LoRA/DoRA for Robot Video Generation](https://daily.dev/posts/fine-tuning-nvidia-cosmos-predict-2-5-with-lora-dora-for-robot-video-generation-uptnktldn) · Hugging Face · 0 upvotes · 0 comments - [What is LoRA and how it lets anyone fine-tune a massive AI model on a single GPU](https://daily.dev/posts/what-is-lora-and-how-it-lets-anyone-fine-tune-a-massive-ai-model-on-a-single-gpu-vfwx1br5h) · Medium · 2 upvotes · 0 comments - [LoRA: Fine-Tuning Billion-Parameter LLMs on a Single GPU](https://daily.dev/posts/lora-fine-tuning-billion-parameter-llms-on-a-single-gpu-0myhkubfu) · Medium · 1 upvotes · 0 comments - [Scale Biology Transformer Models with PyTorch and NVIDIA BioNeMo Recipes](https://daily.dev/posts/scale-biology-transformer-models-with-pytorch-and-nvidia-bionemo-recipes-wejkmytas) · NVIDIA Developer · 0 upvotes · 0 comments - [How to Fine-Tune an LLM on NVIDIA GPUs With Unsloth](https://daily.dev/posts/how-to-fine-tune-an-llm-on-nvidia-gpus-with-unsloth-lfqgsiuoc) · NVIDIA · 2 upvotes · 0 comments --- Tags: [#ai](https://daily.dev/tags/ai), [#lora](https://daily.dev/tags/lora) [View this post on daily.dev](https://daily.dev/posts/fine-tuning-biological-foundation-models-with-lora-using-nvidia-bionemo-recipes-veoulundb)