Migrating ASP.NET MVC from .NET Framework to modern .NET requires understanding fundamental architectural changes including middleware-based pipelines, built-in dependency injection, and environment-driven configuration. The guide recommends an incremental migration strategy for production applications, starting with extracting business logic into class libraries targeting .NET Standard, then creating a new ASP.NET Core project and migrating controllers, views, routing, configuration, and authentication step-by-step. Critical areas include replacing Web.config with appsettings.json, updating authentication from Forms Auth to ASP.NET Core Identity, migrating static files to wwwroot, and validating data access patterns. The approach emphasizes treating this as a web host rewrite while reusing business logic, with thorough testing and gradual production cutover to minimize risk.