--- title: MIT and Broad Institute researchers break diffraction... description: MIT and Broad Institute researchers have developed U-STORM (Upconversion enabled Stochastic Optical Reconstruction Microscopy), a super-resolution imaging... canonical: https://daily.dev/posts/mit-and-broad-institute-researchers-break-diffraction-barrier-in-super-resolution-microscopy-4euoofh3p twitter:card: summary_large_image twitter:site: @dailydotdev og:type: website og:site_name: daily.dev og:title: MIT and Broad Institute researchers break diffraction barrier in super-resolution microscopy | daily.dev og:description: MIT and Broad Institute researchers have developed U-STORM (Upconversion enabled Stochastic Optical Reconstruction Microscopy), a super-resolution imaging... og:url: https://daily.dev/posts/mit-and-broad-institute-researchers-break-diffraction-barrier-in-super-resolution-microscopy-4euoofh3p og:image: https://api.daily.dev/og/posts/4EuOOFh3P.png og:image:alt: MIT and Broad Institute researchers break diffraction barrier in super-resolution microscopy og:image:width: 1200 og:image:height: 630 og:locale: en --- > ## Documentation Index > Fetch the complete documentation index at: https://daily.dev/llms.txt > Use this file to discover all available pages before exploring further. # MIT and Broad Institute researchers break diffraction barrier in super-resolution microscopy **[MIT News](https://daily.dev/sources/mit)** · 3 min read · 0 upvotes · 0 comments ## Summary MIT and Broad Institute researchers have developed U-STORM (Upconversion enabled Stochastic Optical Reconstruction Microscopy), a super-resolution imaging platform using engineered upconverting nanoparticles (UCNPs) that blink spontaneously and indefinitely. This overcomes a long-held assumption that UCNPs were non-blinking and unsuitable for STORM-based imaging. U-STORM achieves sub-angstrom localization precision (0.6 Å) by collecting over 88,000 localization events from a single particle, operates with a single near-infrared laser for simultaneous multicolor imaging, and requires no specialized imaging buffers or oxygen scavengers. The technology was demonstrated by mapping epidermal growth factor receptor structures in biological samples and is published in Nature Nanotechnology. ## Full article daily.dev links to this article rather than hosting it. Read it at the original source: ## Similar posts on daily.dev - [MIT researchers advance toward greater bandwidth, more energy-efficient communications](https://daily.dev/posts/mit-researchers-advance-toward-greater-bandwidth-more-energy-efficient-communications-15r5c3q70) · MIT News · 0 upvotes · 0 comments - [UC San Diego Advances Quantum Metamaterials for Ultrafast Optical Computing](https://daily.dev/posts/uc-san-diego-advances-quantum-metamaterials-for-ultrafast-optical-computing-pbopmu5y3) · The Quantum Insider · 0 upvotes · 0 comments - [Imaging technique captures ultrafast electron and atom dynamics in chemical reactions](https://daily.dev/posts/imaging-technique-captures-ultrafast-electron-and-atom-dynamics-in-chemical-reactions-6ww8hc0ue) · Phys.org · 0 upvotes · 0 comments - [Single-molecule tracker illuminates workings of cancer-related proteins](https://daily.dev/posts/single-molecule-tracker-illuminates-workings-of-cancer-related-proteins-t11x0ujdt) · MIT News · 0 upvotes · 0 comments - [New Device Can Take Photographs With a Single Atom](https://daily.dev/posts/new-device-can-take-photographs-with-a-single-atom-6fbtp5tfi) · IEEE Spectrum · 0 upvotes · 0 comments --- Tags: [#nanotechnology](https://daily.dev/tags/nanotechnology) [View this post on daily.dev](https://daily.dev/posts/mit-and-broad-institute-researchers-break-diffraction-barrier-in-super-resolution-microscopy-4euoofh3p) ```json {"@context":"https://schema.org","@graph":[{"@type":"Organization","@id":"https://daily.dev/#organization","name":"daily.dev","url":"https://daily.dev","logo":{"@type":"ImageObject","url":"https://daily.dev/apple-touch-icon.png","width":180,"height":180},"sameAs":["https://twitter.com/dailydotdev","https://github.com/dailydotdev","https://www.linkedin.com/company/daily-dev-ltd"]},{"@type":"WebSite","@id":"https://daily.dev/#website","url":"https://daily.dev","name":"daily.dev","publisher":{"@id":"https://daily.dev/#organization"},"potentialAction":{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https://daily.dev/search?q={search_term_string}"},"query-input":"required name=search_term_string"}}]} {"@context":"https://schema.org","@type":"TechArticle","headline":"MIT and Broad Institute researchers break diffraction barrier in super-resolution microscopy","url":"https://daily.dev/posts/mit-and-broad-institute-researchers-break-diffraction-barrier-in-super-resolution-microscopy-4euoofh3p","mainEntityOfPage":{"@type":"WebPage","@id":"https://daily.dev/posts/mit-and-broad-institute-researchers-break-diffraction-barrier-in-super-resolution-microscopy-4euoofh3p"},"datePublished":"2026-07-29T17:06:35.222Z","dateModified":"2026-07-29T17:07:08.287Z","description":"MIT and Broad Institute researchers have developed U-STORM (Upconversion enabled Stochastic Optical Reconstruction Microscopy), a super-resolution imaging...","image":"https://media.daily.dev/image/upload/f_auto,q_auto/v1/posts/f29253194ce9502e7e8fa933ebe1c62f?_a=AQAEuop","thumbnailUrl":"https://media.daily.dev/image/upload/f_auto,q_auto/v1/posts/f29253194ce9502e7e8fa933ebe1c62f?_a=AQAEuop","isAccessibleForFree":true,"articleSection":"MIT News","inLanguage":"en","publisher":{"@type":"Organization","name":"daily.dev","url":"https://daily.dev","logo":{"@type":"ImageObject","url":"https://daily.dev/apple-touch-icon.png","width":180,"height":180}},"author":{"@type":"Organization","name":"MIT News","logo":"https://media.daily.dev/image/upload/t_logo,f_auto/v1/logos/881e20a40aa44b12ba4bd27f5c14289d","url":"https://daily.dev/sources/mit"},"commentCount":0,"discussionUrl":"https://daily.dev/posts/mit-and-broad-institute-researchers-break-diffraction-barrier-in-super-resolution-microscopy-4euoofh3p","interactionStatistic":[{"@type":"InteractionCounter","interactionType":{"@type":"LikeAction"},"userInteractionCount":0},{"@type":"InteractionCounter","interactionType":{"@type":"CommentAction"},"userInteractionCount":0}],"keywords":"nanotechnology","timeRequired":"PT3M"} {"@context":"https://schema.org","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://daily.dev"},{"@type":"ListItem","position":2,"name":"MIT News","item":"https://daily.dev/sources/mit"},{"@type":"ListItem","position":3,"name":"MIT and Broad Institute researchers break diffraction barrier in super-resolution microscopy"}]} ```