--- title: New tissue models could help researchers develop drugs... description: MIT engineers developed advanced tissue models that accurately replicate liver architecture, including blood vessels and immune cells, to study metabolic... canonical: https://daily.dev/posts/new-tissue-models-could-help-researchers-develop-drugs-for-liver-disease-jigzglmtd twitter:card: summary_large_image twitter:site: @dailydotdev og:type: website og:site_name: daily.dev og:title: New tissue models could help researchers develop drugs for liver disease | daily.dev og:description: MIT engineers developed advanced tissue models that accurately replicate liver architecture, including blood vessels and immune cells, to study metabolic... og:url: https://daily.dev/posts/new-tissue-models-could-help-researchers-develop-drugs-for-liver-disease-jigzglmtd og:image: https://api.daily.dev/og/posts/jIgzGlMTD.png og:image:alt: New tissue models could help researchers develop drugs for liver disease og:image:width: 1200 og:image:height: 630 og:locale: en --- > ## Documentation Index > Fetch the complete documentation index at: https://daily.dev/llms.txt > Use this file to discover all available pages before exploring further. # New tissue models could help researchers develop drugs for liver disease **[MIT News](https://daily.dev/sources/mit)** · 6 min read · 0 upvotes · 0 comments ## Summary MIT engineers developed advanced tissue models that accurately replicate liver architecture, including blood vessels and immune cells, to study metabolic dysfunction-associated steatotic liver disease (MASLD). The microphysiological systems can model inflammation, insulin resistance, and metabolic dysfunction in early-stage liver disease. In separate research, the team used an earlier model to study resmetirom, finding it can trigger inflammatory responses that may explain why the drug only helps 30% of MASH patients. These models enable researchers to identify drug targets, validate treatments, and understand disease progression more effectively than animal models. ## Full article daily.dev links to this article rather than hosting it. 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