PCI DSS v4.0.1 demands continuous monitoring and real-time detection rather than periodic audits, which creates challenges in cloud and Kubernetes environments where workloads are ephemeral and configurations drift. Sysdig's CNAPP addresses this by mapping runtime security capabilities to specific PCI requirements: network segmentation validation via kernel-level traffic observation, configuration drift detection, file integrity monitoring for stored data, behavior-based malware detection using Falco rules, runtime-context-aware vulnerability prioritization, identity and access correlation, and continuous audit evidence collection. The post walks through how to operationalize Sysdig for PCI by defining dynamic scope with Zones, applying PCI-aligned policies, configuring runtime detections, and exporting evidence to data warehouses or GRC tools.