CISOs face growing blind spots as cloud environments and agentic AI expand the attack surface beyond what most security tools can observe. Runtime telemetry — knowing what is actually executing in production — is positioned as the foundational layer for modern security programs. Key risk factors include agent entitlements, agent-to-agent communication, model poisoning, protocol risks (MCP, A2A, ACP, ANP), and business logic abuse. Sysdig's 555 benchmark (5 seconds to detect, 5 minutes to correlate, 5 minutes to respond) illustrates the machine-speed timescales required. Runtime insights are framed as essential for observability, traceability, and explainability of AI-enabled applications, helping security teams cut noise and prioritize real threats.